Assay Detail
Binding
CHEMBL4255809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ERG expressed in CHO cells at -80 mV holding potential measured after 3 minutes by automated whole cell patch clamp Qpatch method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.35 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828585 | — | — | 1 | 5.85 |
| CHEMBL3827961 | — | — | 1 | 5.50 |
| CHEMBL4278050 | — | — | 1 | 5.41 |
| CHEMBL4288709 | — | — | 1 | 5.34 |
| CHEMBL4284707 | — | — | 1 | 5.06 |
| CHEMBL4288408 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828585 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3827961 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4278050 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4288709 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4284707 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4288408 | — | IC50 | = | 12100.0 | nM | 4.92 |