Assay Detail
Binding
CHEMBL4256086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus MraY expressed in Escherichia coli membrane using Park's nucleotide as substrate pretreated for 30 mins followed by substrate addition measured up to 2 mins by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase (CHEMBL1770035) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 10.50 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4286766 | — | — | 1 | 10.80 |
| CHEMBL4279378 | — | — | 1 | 10.66 |
| CHEMBL4284923 | — | — | 1 | 10.03 |
| CHEMBL4283345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4286766 | — | IC50 | = | 0.0157 | nM | 10.80 |
| CHEMBL4279378 | — | IC50 | = | 0.0221 | nM | 10.66 |
| CHEMBL4284923 | — | IC50 | = | 0.093 | nM | 10.03 |
| CHEMBL4283345 | — | IC50 | = | 0.004 | nM | - |