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Assay Detail

CHEMBL4256097

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ASK1 (unknown origin) by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase kinase kinase 5 (CHEMBL5285)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bioactive Indolocarbazoles from the Marine-Derived Streptomyces sp. DT-A61.
Wang JN, Zhang HJ, Li JQ, Ding WJ, Ma ZJ.
J Nat Prod (2018) 81 : 949 -956
PubMed 29558119 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.21 9.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388978 STAUROSPORINE 1 9.16
CHEMBL4284524 1 6.13
CHEMBL4277459 1 6.11
CHEMBL4288105 1 5.96
CHEMBL4294912 1 5.52
CHEMBL4291517 1 5.39
CHEMBL4287662 1 5.19
CHEMBL4284275 1 -
CHEMBL4279758 1 -
CHEMBL4280872 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388978 STAUROSPORINE IC50 = 0.69 nM 9.16
CHEMBL4284524 IC50 = 740.0 nM 6.13
CHEMBL4277459 IC50 = 770.0 nM 6.11
CHEMBL4288105 IC50 = 1100.0 nM 5.96
CHEMBL4294912 IC50 = 3000.0 nM 5.52
CHEMBL4291517 IC50 = 4100.0 nM 5.39
CHEMBL4287662 IC50 = 6400.0 nM 5.19
CHEMBL4284275 IC50 > 50000.0 nM -
CHEMBL4279758 IC50 > 50000.0 nM -
CHEMBL4280872 IC50 > 50000.0 nM -