Assay Detail
Functional
CHEMBL4256370
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Cytotoxicity against human MG63 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MG-63 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New Hybrids Derived from Podophyllic Aldehyde and Diterpenylhydroquinones with Selectivity toward Osteosarcoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.65 | 8.15 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.15 |
| CHEMBL309880 | PODOPHYLLIC ALDEHYDE | — | 1 | 7.22 |
| CHEMBL4282812 | — | — | 1 | 6.82 |
| CHEMBL23741 | — | — | 1 | 6.39 |
| CHEMBL4284818 | — | — | 1 | 5.69 |
| CHEMBL4279359 | — | — | 1 | 5.65 |
| CHEMBL4276980 | — | — | 1 | - |
| CHEMBL4287617 | — | — | 1 | - |
| CHEMBL4291040 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL309880 | PODOPHYLLIC ALDEHYDE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4282812 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL23741 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4284818 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4279359 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4276980 | — | Activity | - | — | - | |
| CHEMBL4287617 | — | Activity | - | — | - | |
| CHEMBL4291040 | — | Activity | - | — | - |