Assay Detail
Binding
CHEMBL4256441
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Inhibition of bacterial ImiS expressed in Escherichia coli BL21(DE3) using imipenem as substrate by spectrometric method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-β-lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.03 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4279447 | — | — | 1 | 5.52 |
| CHEMBL185401 | — | — | 1 | 5.44 |
| CHEMBL4285550 | — | — | 1 | 5.16 |
| CHEMBL4286700 | — | — | 1 | 5.12 |
| CHEMBL4289683 | — | — | 1 | 5.11 |
| CHEMBL4284041 | — | — | 1 | 5.11 |
| CHEMBL4279327 | — | — | 1 | 4.82 |
| CHEMBL4291943 | — | — | 1 | 4.80 |
| CHEMBL4277437 | — | — | 1 | 4.78 |
| CHEMBL185320 | — | — | 1 | 4.74 |
| CHEMBL4103105 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4279447 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL185401 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4285550 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4286700 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4289683 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4284041 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4279327 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4291943 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4277437 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL185320 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4103105 | — | IC50 | = | 19100.0 | nM | 4.72 |