Assay Detail
Functional
CHEMBL4256723
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Cytotoxicity against human NCI-H2122 cells incubated for 4 days
115
Total Activities
115
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2122 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 115 | 6.08 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4280726 | — | — | 1 | 8.00 |
| CHEMBL4281790 | — | — | 1 | 7.96 |
| CHEMBL4287868 | — | — | 1 | 7.55 |
| CHEMBL4277334 | — | — | 1 | 7.51 |
| CHEMBL4287972 | — | — | 1 | 7.51 |
| CHEMBL4292414 | — | — | 1 | 7.24 |
| CHEMBL4277212 | — | — | 1 | 7.09 |
| CHEMBL4284467 | — | — | 1 | 7.07 |
| CHEMBL4291374 | — | — | 1 | 7.01 |
| CHEMBL4284593 | — | — | 1 | 6.96 |
| CHEMBL4286400 | — | — | 1 | 6.82 |
| CHEMBL4281436 | — | — | 1 | 6.80 |
| CHEMBL4281955 | — | — | 1 | 6.77 |
| CHEMBL4293968 | — | — | 1 | 6.66 |
| CHEMBL4293207 | — | — | 1 | 6.58 |
| CHEMBL4281058 | — | — | 1 | 6.54 |
| CHEMBL4289805 | — | — | 1 | 6.54 |
| CHEMBL4290533 | — | — | 1 | 6.54 |
| CHEMBL4282657 | — | — | 1 | 6.51 |
| CHEMBL4293954 | — | — | 1 | 6.50 |
| CHEMBL4277276 | — | — | 1 | 6.50 |
| CHEMBL4281937 | — | — | 1 | 6.46 |
| CHEMBL4286036 | — | — | 1 | 6.42 |
| CHEMBL4278838 | — | — | 1 | 6.40 |
| CHEMBL4289459 | — | — | 1 | 6.39 |
| CHEMBL4285362 | — | — | 1 | 6.36 |
| CHEMBL4288963 | — | — | 1 | 6.34 |
| CHEMBL4282309 | — | — | 1 | 6.31 |
| CHEMBL4280302 | — | — | 1 | 6.22 |
| CHEMBL4292364 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4280726 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4281790 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4287868 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4287972 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4277334 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4292414 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4277212 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4284467 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4291374 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4284593 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4286400 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4281436 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4281955 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4293968 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4293207 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4281058 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4290533 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4289805 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4282657 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4277276 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4293954 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4281937 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4286036 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4278838 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4289459 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4285362 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4288963 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4282309 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4280302 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4292364 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4290938 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4277224 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4281224 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4284504 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4279565 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4292902 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4289513 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4285229 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4280020 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4285185 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4292480 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4287924 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4283698 | — | EC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL4278047 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4293629 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4293616 | — | EC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL4285862 | — | EC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4280243 | — | EC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL4283039 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4295168 | — | EC50 | = | 5100.0 | nM | 5.29 |