Assay Detail
Binding
CHEMBL4256842
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA2 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.07 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL4286620 | — | — | 1 | 7.03 |
| CHEMBL4285851 | — | — | 1 | 6.86 |
| CHEMBL4278617 | — | — | 1 | 6.43 |
| CHEMBL4292591 | — | — | 1 | 6.43 |
| CHEMBL4294703 | — | — | 1 | 6.17 |
| CHEMBL4283637 | — | — | 1 | 6.14 |
| CHEMBL4294527 | — | — | 1 | 6.12 |
| CHEMBL4291115 | — | — | 1 | 6.11 |
| CHEMBL4282079 | — | — | 1 | 6.08 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 6.02 |
| CHEMBL4282828 | — | — | 1 | 6.02 |
| CHEMBL4288405 | — | — | 1 | 6.00 |
| CHEMBL4279796 | — | — | 1 | 5.96 |
| CHEMBL4287685 | — | — | 1 | 5.90 |
| CHEMBL4286489 | — | — | 1 | 5.86 |
| CHEMBL4292967 | — | — | 1 | 5.78 |
| CHEMBL4287699 | — | — | 1 | 5.68 |
| CHEMBL4292271 | — | — | 1 | 5.63 |
| CHEMBL4289589 | — | — | 1 | 5.48 |
| CHEMBL4293437 | — | — | 1 | 5.47 |
| CHEMBL4289262 | — | — | 1 | 5.36 |
| CHEMBL4284307 | — | — | 1 | 5.14 |
| CHEMBL4294946 | — | — | 1 | - |
| CHEMBL4290328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4286620 | — | Ki | = | 94.3 | nM | 7.03 |
| CHEMBL4285851 | — | Ki | = | 136.9 | nM | 6.86 |
| CHEMBL4278617 | — | Ki | = | 373.2 | nM | 6.43 |
| CHEMBL4292591 | — | Ki | = | 368.7 | nM | 6.43 |
| CHEMBL4294703 | — | Ki | = | 667.8 | nM | 6.17 |
| CHEMBL4283637 | — | Ki | = | 728.5 | nM | 6.14 |
| CHEMBL4294527 | — | Ki | = | 762.3 | nM | 6.12 |
| CHEMBL4291115 | — | Ki | = | 771.7 | nM | 6.11 |
| CHEMBL4282079 | — | Ki | = | 842.3 | nM | 6.08 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL4282828 | — | Ki | = | 951.3 | nM | 6.02 |
| CHEMBL4288405 | — | Ki | = | 997.6 | nM | 6.00 |
| CHEMBL4279796 | — | Ki | = | 1107.5 | nM | 5.96 |
| CHEMBL4287685 | — | Ki | = | 1253.5 | nM | 5.90 |
| CHEMBL4286489 | — | Ki | = | 1394.7 | nM | 5.86 |
| CHEMBL4292967 | — | Ki | = | 1647.7 | nM | 5.78 |
| CHEMBL4287699 | — | Ki | = | 2103.1 | nM | 5.68 |
| CHEMBL4292271 | — | Ki | = | 2343.9 | nM | 5.63 |
| CHEMBL4289589 | — | Ki | = | 3333.8 | nM | 5.48 |
| CHEMBL4293437 | — | Ki | = | 3406.2 | nM | 5.47 |
| CHEMBL4289262 | — | Ki | = | 4416.5 | nM | 5.36 |
| CHEMBL4284307 | — | Ki | = | 7290.5 | nM | 5.14 |
| CHEMBL4294946 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4290328 | — | Ki | > | 10000.0 | nM | - |