Assay Detail
Functional
CHEMBL4256853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.80 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4283608 | — | — | 1 | 9.92 |
| CHEMBL4287941 | — | — | 1 | 9.55 |
| CHEMBL4281149 | — | — | 1 | 9.42 |
| CHEMBL4282356 | — | — | 1 | 8.68 |
| CHEMBL3341972 | — | — | 1 | 8.22 |
| CHEMBL4284672 | — | — | 1 | 7.96 |
| CHEMBL4277299 | — | — | 1 | 7.92 |
| CHEMBL3115775 | — | — | 1 | 7.77 |
| CHEMBL3115774 | — | — | 1 | 7.77 |
| CHEMBL4291346 | — | — | 1 | 7.75 |
| CHEMBL4291464 | — | — | 1 | 7.64 |
| CHEMBL4279605 | — | — | 1 | 7.42 |
| CHEMBL4278772 | — | — | 1 | 7.42 |
| CHEMBL4277207 | — | — | 1 | 6.92 |
| CHEMBL4280693 | — | — | 1 | 6.68 |
| CHEMBL4287509 | — | — | 1 | 6.65 |
| CHEMBL4285167 | — | — | 1 | 6.58 |
| CHEMBL4292357 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4283608 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL4287941 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL4281149 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL4282356 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3341972 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4284672 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4277299 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3115775 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3115774 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4291346 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4291464 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4279605 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4278772 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4277207 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4280693 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4287509 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL4285167 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4292357 | — | IC50 | = | 750.0 | nM | 6.12 |