Assay Detail
Binding
CHEMBL4256920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of miR-21 RNA in human A498 cells assessed as potentiation of topotecan-induced cytotoxicity by measuring topotecan IC50 at 10 uM after 72 hrs by XTT assay (Rvb = 1 uM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.05 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4280638 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4280638 | — | IC50 | = | 90.0 | nM | 7.05 |