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Assay Detail

CHEMBL4256949

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human C-terminal FLAG-tagged JARID1A (1 to 1090 residues) expressed in baculovirus infected sf9 cells using H3K4me3-biotin peptide as substrate after 30 mins in presence of alpha-ketoglutaric acid by LANCE TR-FRET assay
ChEMBL ↗
139
Total Activities
139
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Lysine-specific demethylase 5A (CHEMBL2424504) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Histone demethylase inhibitors
(2016)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 6.78 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4288537 — — 1 7.00
CHEMBL4292444 — — 1 7.00
CHEMBL4282124 — — 1 7.00
CHEMBL4281159 — — 1 7.00
CHEMBL4287296 — — 1 7.00
CHEMBL4285840 — — 1 7.00
CHEMBL4283065 — — 1 7.00
CHEMBL4282036 — — 1 7.00
CHEMBL4287102 — — 1 7.00
CHEMBL4287797 — — 1 7.00
CHEMBL4286290 — — 1 7.00
CHEMBL4281202 — — 1 7.00
CHEMBL4280506 — — 1 7.00
CHEMBL4226553 — — 1 7.00
CHEMBL4284855 — — 1 7.00
CHEMBL4286275 — — 1 7.00
CHEMBL4225665 — — 1 7.00
CHEMBL4226861 — — 1 7.00
CHEMBL4227075 — — 1 7.00
CHEMBL4227544 — — 1 7.00
CHEMBL4228384 — — 1 7.00
CHEMBL4227668 — — 1 7.00
CHEMBL4228839 — — 1 7.00
CHEMBL4228902 — — 1 7.00
CHEMBL4283282 — — 1 7.00
CHEMBL4227799 — — 1 7.00
CHEMBL4277756 — — 1 7.00
CHEMBL4276814 — — 1 7.00
CHEMBL4287794 — — 1 7.00
CHEMBL4292883 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4227668 — IC50 = 100.0 nM 7.00
CHEMBL4283065 — IC50 = 100.0 nM 7.00
CHEMBL4287102 — IC50 = 100.0 nM 7.00
CHEMBL4294656 — IC50 = 100.0 nM 7.00
CHEMBL4279637 — IC50 = 100.0 nM 7.00
CHEMBL4283497 — IC50 = 100.0 nM 7.00
CHEMBL4287567 — IC50 = 100.0 nM 7.00
CHEMBL4287797 — IC50 = 100.0 nM 7.00
CHEMBL4286290 — IC50 = 100.0 nM 7.00
CHEMBL4226553 — IC50 = 100.0 nM 7.00
CHEMBL4227544 — IC50 = 100.0 nM 7.00
CHEMBL4228384 — IC50 = 100.0 nM 7.00
CHEMBL4227075 — IC50 = 100.0 nM 7.00
CHEMBL4292524 — IC50 = 100.0 nM 7.00
CHEMBL4228839 — IC50 = 100.0 nM 7.00
CHEMBL4228902 — IC50 = 100.0 nM 7.00
CHEMBL4226861 — IC50 = 100.0 nM 7.00
CHEMBL4283282 — IC50 = 100.0 nM 7.00
CHEMBL4225665 — IC50 = 100.0 nM 7.00
CHEMBL4288537 — IC50 = 100.0 nM 7.00
CHEMBL4284855 — IC50 = 100.0 nM 7.00
CHEMBL4227799 — IC50 = 100.0 nM 7.00
CHEMBL4292883 — IC50 = 100.0 nM 7.00
CHEMBL4276814 — IC50 = 100.0 nM 7.00
CHEMBL4287794 — IC50 = 100.0 nM 7.00
CHEMBL4283926 — IC50 = 100.0 nM 7.00
CHEMBL4287296 — IC50 = 100.0 nM 7.00
CHEMBL4281159 — IC50 = 100.0 nM 7.00
CHEMBL4282124 — IC50 = 100.0 nM 7.00
CHEMBL4292444 — IC50 = 100.0 nM 7.00
CHEMBL4289695 — IC50 = 100.0 nM 7.00
CHEMBL4291083 — IC50 = 100.0 nM 7.00
CHEMBL4294132 — IC50 = 100.0 nM 7.00
CHEMBL4295216 — IC50 = 100.0 nM 7.00
CHEMBL4278760 — IC50 = 100.0 nM 7.00
CHEMBL4285045 — IC50 = 100.0 nM 7.00
CHEMBL4285436 — IC50 = 100.0 nM 7.00
CHEMBL4286275 — IC50 = 100.0 nM 7.00
CHEMBL4282036 — IC50 = 100.0 nM 7.00
CHEMBL4279612 — IC50 = 100.0 nM 7.00
CHEMBL4293050 — IC50 = 100.0 nM 7.00
CHEMBL4294087 — IC50 = 100.0 nM 7.00
CHEMBL4287561 — IC50 = 100.0 nM 7.00
CHEMBL4281578 — IC50 = 100.0 nM 7.00
CHEMBL4291175 — IC50 = 100.0 nM 7.00
CHEMBL4287020 — IC50 = 100.0 nM 7.00
CHEMBL4287394 — IC50 = 100.0 nM 7.00
CHEMBL4288436 — IC50 = 100.0 nM 7.00
CHEMBL4291477 — IC50 = 100.0 nM 7.00
CHEMBL4285840 — IC50 = 100.0 nM 7.00