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Assay Detail

CHEMBL4257029

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human NCI-H157 cells expressing mutant KRAS incubated for 72 hrs by MTS assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H157
Confidence 1 — Organism
Curated By Intermediate

Target

NCI-H157 (CHEMBL614783)
Type CELL-LINE
Organism Homo sapiens

Publication

Compounds, compositions and methods for inhibiting cnksr1
(2016)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.12 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4285086 1 7.00
CHEMBL4288751 1 6.30
CHEMBL4278147 1 5.92
CHEMBL4278841 1 5.82
CHEMBL4278527 1 5.39
CHEMBL4277811 1 5.28
CHEMBL4277129 1 5.19
CHEMBL4293956 1 5.08
CHEMBL4280622 1 5.00
CHEMBL4294863 1 4.83
CHEMBL4293825 1 4.78
CHEMBL4282291 1 4.60
CHEMBL4286687 1 4.41
CHEMBL4282649 1 4.26
CHEMBL4283706 1 4.07
CHEMBL4287729 1 4.00
CHEMBL4290768 1 -
CHEMBL4291817 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4285086 IC50 = 100.0 nM 7.00
CHEMBL4288751 IC50 = 500.0 nM 6.30
CHEMBL4278147 IC50 = 1200.0 nM 5.92
CHEMBL4278841 IC50 = 1500.0 nM 5.82
CHEMBL4278527 IC50 = 4100.0 nM 5.39
CHEMBL4277811 IC50 = 5200.0 nM 5.28
CHEMBL4277129 IC50 = 6500.0 nM 5.19
CHEMBL4293956 IC50 = 8400.0 nM 5.08
CHEMBL4280622 IC50 = 10000.0 nM 5.00
CHEMBL4294863 IC50 = 14700.0 nM 4.83
CHEMBL4293825 IC50 = 16600.0 nM 4.78
CHEMBL4282291 IC50 = 25000.0 nM 4.60
CHEMBL4286687 IC50 = 39100.0 nM 4.41
CHEMBL4282649 IC50 = 55100.0 nM 4.26
CHEMBL4283706 IC50 = 85000.0 nM 4.07
CHEMBL4287729 IC50 = 100000.0 nM 4.00
CHEMBL4290768 IC50 - -
CHEMBL4291817 IC50 - -