Assay Detail
Functional
CHEMBL4257037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NSCLC cells expressing mutant KRAS assessed as inhibition of 2D cell growth incubated for 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NSCLC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Compounds, compositions and methods for inhibiting cnksr1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.82 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4277129 | — | — | 1 | 7.00 |
| CHEMBL4285086 | — | — | 1 | 7.00 |
| CHEMBL4277811 | — | — | 1 | 6.70 |
| CHEMBL4288751 | — | — | 1 | 6.30 |
| CHEMBL4278527 | — | — | 1 | 6.22 |
| CHEMBL4293956 | — | — | 1 | 6.10 |
| CHEMBL4278841 | — | — | 1 | 6.00 |
| CHEMBL4280622 | — | — | 1 | 5.80 |
| CHEMBL4286687 | — | — | 1 | 5.80 |
| CHEMBL4278147 | — | — | 1 | 5.37 |
| CHEMBL4294863 | — | — | 1 | 5.29 |
| CHEMBL4282142 | — | — | 1 | 5.22 |
| CHEMBL4283706 | — | — | 1 | 4.92 |
| CHEMBL4282649 | — | — | 1 | 4.86 |
| CHEMBL4282291 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4277129 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4285086 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4277811 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4288751 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4278527 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4293956 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4278841 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4280622 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4286687 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4278147 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4294863 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4282142 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4283706 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL4282649 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4282291 | — | IC50 | = | 19000.0 | nM | 4.72 |