Assay Detail
Binding
CHEMBL4257130
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Inhibition of rabbit NHE2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium/hydrogen exchanger 2 (CHEMBL3770) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Nhe3-binding compounds and methods for inhibiting phosphate transport
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.47 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | — | 1 | 6.30 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 6.00 |
| CHEMBL3897683 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517986 | 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL945 | AMILORIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3897683 | — | IC50 | = | 80000.0 | nM | 4.10 |