Assay Detail
Binding
CHEMBL4257178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CYP21 (unknown origin) expressed in human AD293 cells using 17alpha-hydroxyprogesterone as substrate pretreated for 60 mins followed by substrate addition and measured after 45 mins by LC/MS analysis
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel cytochrome p450 inhibitors and their method of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.76 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284756 | — | — | 1 | 7.14 |
| CHEMBL4279221 | — | — | 1 | 7.07 |
| CHEMBL4287787 | — | — | 1 | 6.80 |
| CHEMBL4127656 | — | — | 1 | 6.72 |
| CHEMBL4291002 | — | — | 1 | 6.60 |
| CHEMBL4279727 | — | — | 1 | 6.54 |
| CHEMBL4128368 | — | — | 1 | 6.50 |
| CHEMBL4127385 | — | — | 1 | 6.47 |
| CHEMBL4126996 | — | — | 1 | 6.41 |
| CHEMBL4128640 | — | — | 1 | 6.38 |
| CHEMBL4129721 | — | — | 1 | 6.37 |
| CHEMBL4288457 | — | — | 1 | 6.31 |
| CHEMBL4126284 | — | — | 1 | 6.28 |
| CHEMBL4288256 | — | — | 1 | 6.28 |
| CHEMBL4128449 | — | — | 1 | 6.27 |
| CHEMBL4127256 | — | — | 1 | 6.25 |
| CHEMBL4279416 | — | — | 1 | 6.23 |
| CHEMBL4127378 | — | — | 1 | 6.16 |
| CHEMBL4126429 | — | — | 1 | 6.13 |
| CHEMBL4286910 | — | — | 1 | 6.11 |
| CHEMBL4126014 | — | — | 1 | 6.08 |
| CHEMBL4283570 | — | — | 1 | 6.07 |
| CHEMBL4127969 | — | — | 1 | 6.00 |
| CHEMBL4283402 | — | — | 1 | 6.00 |
| CHEMBL4289268 | — | — | 1 | 6.00 |
| CHEMBL4127399 | — | — | 1 | 5.96 |
| CHEMBL4289969 | — | — | 1 | 5.92 |
| CHEMBL4129428 | — | — | 1 | 5.92 |
| CHEMBL4126816 | — | — | 1 | 5.92 |
| CHEMBL4292267 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284756 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4279221 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4287787 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4127656 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4291002 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4279727 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL4128368 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL4127385 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4126996 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL4128640 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL4129721 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4288457 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4126284 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4288256 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4128449 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4127256 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL4279416 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL4127378 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4126429 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4286910 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4126014 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4283570 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4127969 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4283402 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4289268 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4127399 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4129428 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4126816 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4292267 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4289969 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4128621 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4280777 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4285546 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4280985 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4126412 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4282398 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4283084 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4284598 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4280378 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4286077 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4288168 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4282697 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4129210 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4287119 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4288241 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4279912 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4281653 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4285301 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4288970 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4283190 | — | IC50 | = | 10000.0 | nM | 5.00 |