Assay Detail
Binding
CHEMBL4257192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CYP21 (unknown origin) expressed in human AD293 cells assessed as reduction in 11-deoxycortisol level preincubated for 60 mins followed by 17alpha-OH-progesterone substrate addition and measured after 45 mins by LC-MS method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome p450 inhibition and their method of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.10 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290805 | — | — | 1 | 7.17 |
| CHEMBL4287608 | — | — | 1 | 6.96 |
| CHEMBL4291856 | — | — | 1 | 6.89 |
| CHEMBL4284316 | — | — | 1 | 6.77 |
| CHEMBL4289930 | — | — | 1 | 6.68 |
| CHEMBL4283588 | — | — | 1 | 6.58 |
| CHEMBL4283318 | — | — | 1 | 6.56 |
| CHEMBL4279058 | — | — | 1 | 6.41 |
| CHEMBL4279441 | — | — | 1 | 6.38 |
| CHEMBL4288383 | — | — | 1 | 6.37 |
| CHEMBL4278076 | — | — | 1 | 6.24 |
| CHEMBL4281307 | — | — | 1 | 6.10 |
| CHEMBL4277054 | — | — | 1 | 6.10 |
| CHEMBL4286761 | — | — | 1 | 6.02 |
| CHEMBL4284620 | — | — | 1 | 5.96 |
| CHEMBL4283034 | — | — | 1 | 5.83 |
| CHEMBL4285420 | — | — | 1 | 5.82 |
| CHEMBL4280259 | — | — | 1 | 5.60 |
| CHEMBL4278033 | — | — | 1 | 5.55 |
| CHEMBL4281673 | — | — | 1 | 5.32 |
| CHEMBL4283221 | — | — | 1 | 5.00 |
| CHEMBL4288652 | — | — | 1 | 5.00 |
| CHEMBL4285744 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290805 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4287608 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4291856 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4284316 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4289930 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4283588 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL4283318 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL4279058 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL4279441 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL4288383 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL4278076 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4281307 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4277054 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4286761 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4284620 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4283034 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4285420 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4280259 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4278033 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4281673 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL4283221 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4288652 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4285744 | — | IC50 | = | 10000.0 | nM | 5.00 |