Assay Detail
Binding
CHEMBL4257286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoblot analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Target
Lysine-specific demethylase 5A/5B (CHEMBL4296073) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Histone demethylase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4289724 | — | — | 1 | 6.00 |
| CHEMBL4279120 | — | — | 1 | 6.00 |
| CHEMBL4283132 | — | — | 1 | 6.00 |
| CHEMBL4278099 | — | — | 1 | 6.00 |
| CHEMBL3787664 | — | — | 1 | 6.00 |
| CHEMBL4284008 | — | — | 1 | 6.00 |
| CHEMBL4286418 | — | — | 1 | 6.00 |
| CHEMBL3786803 | — | — | 1 | 6.00 |
| CHEMBL4278927 | — | — | 1 | 6.00 |
| CHEMBL4280142 | — | — | 1 | 6.00 |
| CHEMBL4289159 | — | — | 1 | 6.00 |
| CHEMBL4290321 | — | — | 1 | 6.00 |
| CHEMBL4288875 | — | — | 1 | 6.00 |
| CHEMBL4281219 | — | — | 1 | 6.00 |
| CHEMBL4285323 | — | — | 1 | 6.00 |
| CHEMBL4281591 | — | — | 1 | 6.00 |
| CHEMBL4282667 | — | — | 1 | 6.00 |
| CHEMBL4290636 | — | — | 1 | 6.00 |
| CHEMBL4278227 | — | — | 1 | 6.00 |
| CHEMBL4282361 | — | — | 1 | 6.00 |
| CHEMBL4283431 | — | — | 1 | 6.00 |
| CHEMBL4277869 | — | — | 1 | 6.00 |
| CHEMBL4280936 | — | — | 1 | - |
| CHEMBL4292111 | — | — | 1 | - |
| CHEMBL4284869 | — | — | 1 | - |
| CHEMBL4279029 | — | — | 1 | - |
| CHEMBL4279259 | — | — | 1 | - |
| CHEMBL4285037 | — | — | 1 | - |
| CHEMBL4280613 | — | — | 1 | - |
| CHEMBL4285705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4289724 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4279120 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4283132 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4278099 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3787664 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4284008 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4286418 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3786803 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4278927 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4280142 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4289159 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4290321 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4277869 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4288875 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4281219 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4285323 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4281591 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4282667 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4290636 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4278227 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4282361 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4283431 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4294777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3786225 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3787133 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4288587 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4285705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4280613 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4285037 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4279259 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4279029 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4284869 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4292111 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4280936 | — | IC50 | > | 10000.0 | nM | - |