Assay Detail
Binding
CHEMBL4257728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of a potent Na<sub>v</sub>1.3 inhibitor with good oral pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4276884 | — | — | 1 | 4.75 |
| CHEMBL4293085 | — | — | 1 | - |
| CHEMBL4276813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4276884 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4293085 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4276813 | — | IC50 | > | 10000.0 | nM | - |