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Assay Detail

CHEMBL4257764

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HepG2 cells after 72 hrs by alamar blue assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Intermediate

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M<sub>1</sub> and M<sub>2</sub>.
Messerer R, Dallanoce C, Matera C, Wehle S, Flammini L, Chirinda B, Bock A, Irmen M, Tränkle C, Barocelli E, Decker M, Sotriffer C, De Amici M, Holzgrabe U.
Medchemcomm (2017) 8 : 1346 -1359
PubMed 30108847 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.49 4.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4287748 1 4.49
CHEMBL4281409 1 -
CHEMBL4292032 1 -
CHEMBL3121476 1 -
CHEMBL3121475 1 -
CHEMBL3121480 1 -
CHEMBL3121477 1 -
CHEMBL95 TACRINE 4.0 1 -
CHEMBL4276885 1 -
CHEMBL4292521 1 -
CHEMBL4285270 1 -
CHEMBL4284343 1 -
CHEMBL382846 1 -
CHEMBL4280937 1 -
CHEMBL32823 1 -
CHEMBL4291154 1 -
CHEMBL4283298 1 -
CHEMBL4279836 1 -
CHEMBL4289232 1 -
CHEMBL4293086 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4287748 IC50 = 32200.0 nM 4.49
CHEMBL4281409 IC50 - -
CHEMBL4292032 IC50 - -
CHEMBL3121476 IC50 - -
CHEMBL3121475 IC50 - -
CHEMBL3121480 IC50 - -
CHEMBL3121477 IC50 - -
CHEMBL95 TACRINE IC50 = 111000.0 nM -
CHEMBL4276885 IC50 - -
CHEMBL4292521 IC50 - -
CHEMBL4285270 IC50 - -
CHEMBL4284343 IC50 - -
CHEMBL382846 IC50 - -
CHEMBL4280937 IC50 - -
CHEMBL32823 IC50 < 1380.0 nM -
CHEMBL4291154 IC50 < 1250.0 nM -
CHEMBL4283298 IC50 > 160000.0 nM -
CHEMBL4279836 IC50 - -
CHEMBL4289232 IC50 - -
CHEMBL4293086 IC50 - -