Assay Detail
Binding
CHEMBL4257801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LDHA using pyruvate as substrate by surface plasmon resonance assay relative to control
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of human lactate dehydrogenase A (LDHA) inhibitors as anticancer agents to inhibit the proliferation of MG-63 osteosarcoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.05 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287503 | — | — | 1 | 6.48 |
| CHEMBL3318469 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287503 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3318469 | — | IC50 | = | 2370.0 | nM | 5.62 |