Assay Detail
Binding
CHEMBL4258345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of almond beta-glucosidase pre-incubated for 5 mins followed by p-nitrophenyl-beta-D-glucopyranoside substrate addition and measured after 30 mins by spectrophotometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Prunus dulcis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Orthoester functionalized <i>N</i>-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.78 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278926 | — | — | 1 | 4.84 |
| CHEMBL4287946 | — | — | 1 | 4.72 |
| CHEMBL408500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278926 | — | IC50 | = | 14570.0 | nM | 4.84 |
| CHEMBL4287946 | — | IC50 | = | 19150.0 | nM | 4.72 |
| CHEMBL408500 | — | IC50 | > | 30000.0 | nM | - |