Assay Detail
Binding
CHEMBL4258356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length GST-fused human CBS assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancer <i>in vitro</i> and <i>in vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.59 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172216 | SIKOKIANIN C | — | 1 | 6.05 |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172216 | SIKOKIANIN C | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | IC50 | = | 7500.0 | nM | 5.12 |