Assay Detail
Binding
CHEMBL4258363
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CBS Y223A mutant assessed as reduction in H2S production using 2 mM S-methylcysteine as substrate preincubated for 3 mins followed by substrate addition
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancer <i>in vitro</i> and <i>in vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.77 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172216 | SIKOKIANIN C | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172216 | SIKOKIANIN C | IC50 | = | 16900.0 | nM | 4.77 |