Assay Detail
Functional
CHEMBL4258368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells harboring CBS SiRNA after 24 hrs by CCK8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor effect of sikokianin C, a selective cystathionine β-synthase inhibitor, against human colon cancer <i>in vitro</i> and <i>in vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.33 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172216 | SIKOKIANIN C | — | 1 | 5.33 |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172216 | SIKOKIANIN C | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL347862 | CARBOXYMETHOXYLAMINE | IC50 | = | 286700.0 | nM | - |