Assay Detail
Binding
CHEMBL4258459
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Inhibition of porcine CEase using para-nitrophenyl butyrate as substrate preincubated with substrate for 5 mins followed by enzyme addition by spectrophotometric method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5,6-Benzoflavones as cholesterol esterase inhibitors: synthesis, biological evaluation and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.22 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285597 | — | — | 1 | 9.14 |
| CHEMBL4277189 | — | — | 1 | 9.14 |
| CHEMBL4292778 | — | — | 1 | 9.08 |
| CHEMBL4278699 | — | — | 1 | 9.00 |
| CHEMBL4289364 | — | — | 1 | 8.97 |
| CHEMBL4282167 | — | — | 1 | 8.94 |
| CHEMBL600169 | — | — | 1 | 8.92 |
| CHEMBL4283803 | — | — | 1 | 8.84 |
| CHEMBL599338 | — | — | 1 | 8.59 |
| CHEMBL4284177 | — | — | 1 | 8.41 |
| CHEMBL4292058 | — | — | 1 | 8.35 |
| CHEMBL4277659 | — | — | 1 | 8.33 |
| CHEMBL4288983 | — | — | 1 | 8.22 |
| CHEMBL4284553 | — | — | 1 | 8.09 |
| CHEMBL4292384 | — | — | 1 | 8.02 |
| CHEMBL4281483 | — | — | 1 | 8.01 |
| CHEMBL4284491 | — | — | 1 | 7.88 |
| CHEMBL4278030 | — | — | 1 | 7.78 |
| CHEMBL4285956 | — | — | 1 | 7.74 |
| CHEMBL4284062 | — | — | 1 | 7.70 |
| CHEMBL4294040 | — | — | 1 | 7.65 |
| CHEMBL4281076 | — | — | 1 | 7.64 |
| CHEMBL4290837 | — | — | 1 | 7.56 |
| CHEMBL4280204 | — | — | 1 | 7.54 |
| CHEMBL4276771 | — | — | 1 | 7.54 |
| CHEMBL4288299 | — | — | 1 | 7.50 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285597 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4277189 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4292778 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL4278699 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL4289364 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL4282167 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL600169 | — | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL4283803 | — | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL599338 | — | IC50 | = | 2.59 | nM | 8.59 |
| CHEMBL4284177 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4292058 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4277659 | — | IC50 | = | 4.69 | nM | 8.33 |
| CHEMBL4288983 | — | IC50 | = | 6.01 | nM | 8.22 |
| CHEMBL4284553 | — | IC50 | = | 8.15 | nM | 8.09 |
| CHEMBL4292384 | — | IC50 | = | 9.55 | nM | 8.02 |
| CHEMBL4281483 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4284491 | — | IC50 | = | 13.11 | nM | 7.88 |
| CHEMBL4278030 | — | IC50 | = | 16.44 | nM | 7.78 |
| CHEMBL4285956 | — | IC50 | = | 18.01 | nM | 7.74 |
| CHEMBL4284062 | — | IC50 | = | 20.05 | nM | 7.70 |
| CHEMBL4294040 | — | IC50 | = | 22.23 | nM | 7.65 |
| CHEMBL4281076 | — | IC50 | = | 23.11 | nM | 7.64 |
| CHEMBL4290837 | — | IC50 | = | 27.79 | nM | 7.56 |
| CHEMBL4280204 | — | IC50 | = | 29.17 | nM | 7.54 |
| CHEMBL4276771 | — | IC50 | = | 29.11 | nM | 7.54 |
| CHEMBL4288299 | — | IC50 | = | 31.35 | nM | 7.50 |
| CHEMBL26260 | BETA-NAPHTHOFLAVONE | IC50 | = | 51.06 | nM | 7.29 |