Assay Detail
Binding
CHEMBL4258535
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Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 10 mins followed by substrate addition at 10 secs intervals measured after 20 mins by fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.09 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.97 |
| CHEMBL4280184 | — | — | 1 | 5.37 |
| CHEMBL4290661 | — | — | 1 | 4.88 |
| CHEMBL4294875 | — | — | 1 | 4.69 |
| CHEMBL4288413 | — | — | 1 | 4.48 |
| CHEMBL4286834 | — | — | 1 | 4.29 |
| CHEMBL4280019 | — | — | 1 | 4.05 |
| CHEMBL4278916 | — | — | 1 | 4.00 |
| CHEMBL4284601 | — | — | 1 | - |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL4280184 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL4290661 | — | IC50 | = | 13150.0 | nM | 4.88 |
| CHEMBL4294875 | — | IC50 | = | 20370.0 | nM | 4.69 |
| CHEMBL4288413 | — | IC50 | = | 33420.0 | nM | 4.48 |
| CHEMBL4286834 | — | IC50 | = | 51640.0 | nM | 4.29 |
| CHEMBL4280019 | — | IC50 | = | 88110.0 | nM | 4.05 |
| CHEMBL4278916 | — | IC50 | = | 99080.0 | nM | 4.00 |
| CHEMBL4284601 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL255231 | LADOSTIGIL | IC50 | > | 100000.0 | nM | - |