Assay Detail
Binding
CHEMBL4259339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of gp41 I37T/N43K double mutant in T20-resistant HIV1 NL4-3 assessed as inhibition of viral infection in Ghost (3)X4/R5 cells after 48 hrs by Bright-Glo luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Envelope glycoprotein gp160 (CHEMBL1293311) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Generation of a long-acting fusion inhibitor against HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.99 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4281745 | — | — | 1 | 8.46 |
| CHEMBL4289957 | — | — | 1 | 7.51 |
| CHEMBL440999 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4281745 | — | IC50 | = | 3.43 | nM | 8.46 |
| CHEMBL4289957 | — | IC50 | = | 31.08 | nM | 7.51 |
| CHEMBL440999 | — | IC50 | > | 2250.0 | nM | - |