Assay Detail
Functional
CHEMBL4259353
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Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.43 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4283239 | — | — | 1 | 5.86 |
| CHEMBL4291034 | — | — | 1 | 5.84 |
| CHEMBL4276683 | — | — | 1 | 5.83 |
| CHEMBL4278157 | — | — | 1 | 5.78 |
| CHEMBL4294435 | — | — | 1 | 5.75 |
| CHEMBL4292939 | — | — | 1 | 5.57 |
| CHEMBL4279760 | — | — | 1 | 5.52 |
| CHEMBL4287219 | — | — | 1 | 5.51 |
| CHEMBL4291401 | — | — | 1 | 5.50 |
| CHEMBL4288002 | — | — | 1 | 5.49 |
| CHEMBL4284622 | — | — | 1 | 5.49 |
| CHEMBL4283859 | — | — | 1 | 5.48 |
| CHEMBL4286073 | — | — | 1 | 5.46 |
| CHEMBL4291355 | — | — | 1 | 5.45 |
| CHEMBL4290628 | — | — | 1 | 5.45 |
| CHEMBL4283560 | — | — | 1 | 5.44 |
| CHEMBL4282349 | — | — | 1 | 5.43 |
| CHEMBL4291830 | — | — | 1 | 5.39 |
| CHEMBL4290952 | — | — | 1 | 5.38 |
| CHEMBL4280403 | — | — | 1 | 5.30 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 5.27 |
| CHEMBL4282746 | — | — | 1 | 5.23 |
| CHEMBL4281208 | — | — | 1 | 5.22 |
| CHEMBL4280106 | — | — | 1 | 5.17 |
| CHEMBL4279289 | — | — | 1 | 5.15 |
| CHEMBL4283090 | — | — | 1 | 5.14 |
| CHEMBL4291085 | — | — | 1 | 5.04 |
| CHEMBL176045 | FANCHININ | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4283239 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4291034 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4276683 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4278157 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4294435 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4292939 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL4279760 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4287219 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4291401 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4288002 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4284622 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4283859 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4286073 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL4291355 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL4290628 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL4283560 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL4282349 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL4291830 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4290952 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL4280403 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL4282746 | — | IC50 | = | 5840.0 | nM | 5.23 |
| CHEMBL4281208 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL4280106 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL4279289 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL4283090 | — | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL4291085 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL176045 | FANCHININ | IC50 | = | 11760.0 | nM | 4.93 |