Assay Detail
ADMET
CHEMBL4259398
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Cytotoxicity against human PBMC-differentiated macrophages treated for 24 hrs followed by compound washout and measured after 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Macrophage cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.06 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 4.28 |
| CHEMBL4289015 | — | — | 1 | 4.09 |
| CHEMBL4281114 | — | — | 1 | 4.07 |
| CHEMBL4284527 | — | — | 1 | 4.06 |
| CHEMBL4290922 | — | — | 1 | 4.05 |
| CHEMBL4288736 | — | — | 1 | 4.04 |
| CHEMBL4283056 | — | — | 1 | 4.04 |
| CHEMBL4292420 | — | — | 1 | 4.04 |
| CHEMBL4288340 | — | — | 1 | 4.02 |
| CHEMBL4281529 | — | — | 1 | 4.01 |
| CHEMBL4292160 | — | — | 1 | 4.01 |
| CHEMBL4280672 | — | — | 1 | 4.01 |
| CHEMBL4278077 | — | — | 1 | - |
| CHEMBL4291324 | — | — | 1 | - |
| CHEMBL4277280 | — | — | 1 | - |
| CHEMBL4287917 | — | — | 1 | - |
| CHEMBL4287589 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL4289015 | — | IC50 | = | 81200.0 | nM | 4.09 |
| CHEMBL4281114 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL4284527 | — | IC50 | = | 87900.0 | nM | 4.06 |
| CHEMBL4290922 | — | IC50 | = | 88600.0 | nM | 4.05 |
| CHEMBL4288736 | — | IC50 | = | 91400.0 | nM | 4.04 |
| CHEMBL4283056 | — | IC50 | = | 90800.0 | nM | 4.04 |
| CHEMBL4292420 | — | IC50 | = | 92100.0 | nM | 4.04 |
| CHEMBL4288340 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL4281529 | — | IC50 | = | 97300.0 | nM | 4.01 |
| CHEMBL4292160 | — | IC50 | = | 96500.0 | nM | 4.01 |
| CHEMBL4280672 | — | IC50 | = | 97400.0 | nM | 4.01 |
| CHEMBL4278077 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4291324 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4277280 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287917 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287589 | — | IC50 | > | 100000.0 | nM | - |