Assay Detail
Functional
CHEMBL4259493
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Antiproliferative activity against human SW48 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW48 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.94 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284722 | — | — | 1 | 7.85 |
| CHEMBL4293265 | — | — | 1 | 7.73 |
| CHEMBL4289882 | — | — | 1 | 7.31 |
| CHEMBL4278540 | — | — | 1 | 7.04 |
| CHEMBL4278129 | — | — | 1 | 6.96 |
| CHEMBL4291840 | — | — | 1 | 6.66 |
| CHEMBL4282006 | — | — | 1 | 6.61 |
| CHEMBL4281583 | — | — | 1 | 6.57 |
| CHEMBL4292206 | — | — | 1 | 6.42 |
| CHEMBL4288793 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284722 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4293265 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL4289882 | — | IC50 | = | 49.4 | nM | 7.31 |
| CHEMBL4278540 | — | IC50 | = | 90.6 | nM | 7.04 |
| CHEMBL4278129 | — | IC50 | = | 108.4 | nM | 6.96 |
| CHEMBL4291840 | — | IC50 | = | 220.2 | nM | 6.66 |
| CHEMBL4282006 | — | IC50 | = | 244.2 | nM | 6.61 |
| CHEMBL4281583 | — | IC50 | = | 270.7 | nM | 6.57 |
| CHEMBL4292206 | — | IC50 | = | 384.2 | nM | 6.42 |
| CHEMBL4288793 | — | IC50 | = | 564.2 | nM | 6.25 |