Assay Detail
Binding
CHEMBL4259681
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Inhibition of recombinant human MAO-A assessed as reduction in H2O2 production preincubated for 30 mins followed by p-tyramine substrate addition measured after 30 mins by amplex red reagent based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Curcumin-based pyrazoline analogues as selective inhibitors of human monoamine oxidase A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.54 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4289477 | — | — | 1 | 7.10 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | 6.99 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 5.44 |
| CHEMBL4290556 | — | — | 1 | 4.71 |
| CHEMBL4287129 | — | — | 1 | 4.58 |
| CHEMBL4279206 | — | — | 1 | 4.40 |
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | - |
| CHEMBL4282674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4289477 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL86304 | MOCLOBEMIDE | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL972 | SELEGILINE | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL4290556 | — | Ki | = | 19550.0 | nM | 4.71 |
| CHEMBL4287129 | — | Ki | = | 26200.0 | nM | 4.58 |
| CHEMBL4279206 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL279390 | LAZABEMIDE | Ki | = | 7900000.0 | nM | - |
| CHEMBL4282674 | — | Ki | = | 192840.0 | nM | - |