Assay Detail
Functional
CHEMBL4259696
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Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of AKT inhibitors bearing a piperidin-4-yl appendant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.74 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285143 | — | — | 1 | 5.43 |
| CHEMBL4281435 | — | — | 1 | 5.01 |
| CHEMBL4284849 | — | — | 1 | 4.99 |
| CHEMBL4283804 | — | — | 1 | 4.86 |
| CHEMBL494089 | GSK-690693 | 1.0 | 1 | 4.85 |
| CHEMBL4277316 | — | — | 1 | 4.85 |
| CHEMBL4292059 | — | — | 1 | 4.82 |
| CHEMBL4284420 | — | — | 1 | 4.71 |
| CHEMBL4214539 | — | — | 1 | 4.68 |
| CHEMBL4287157 | — | — | 1 | 4.64 |
| CHEMBL4280704 | — | — | 1 | 4.50 |
| CHEMBL4282775 | — | — | 1 | 4.49 |
| CHEMBL4291663 | — | — | 1 | 4.47 |
| CHEMBL4292972 | — | — | 1 | 4.44 |
| CHEMBL4278081 | — | — | 1 | 4.43 |
| CHEMBL4276919 | — | — | 1 | - |
| CHEMBL4288244 | — | — | 1 | - |
| CHEMBL4280343 | — | — | 1 | - |
| CHEMBL4295080 | — | — | 1 | - |
| CHEMBL4278247 | — | — | 1 | - |
| CHEMBL4290887 | — | — | 1 | - |
| CHEMBL4286037 | — | — | 1 | - |
| CHEMBL4279320 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285143 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4281435 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4284849 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4283804 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL494089 | GSK-690693 | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4277316 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4292059 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4284420 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4214539 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4287157 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4280704 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4282775 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL4291663 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL4292972 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL4278081 | — | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL4276919 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4288244 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4280343 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4295080 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4278247 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4290887 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4286037 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4279320 | — | IC50 | > | 40000.0 | nM | - |