Assay Detail
Functional
CHEMBL4259829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human D3 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 4 hrs by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D<sub>3</sub> receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.85 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285942 | — | — | 1 | 10.59 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 10.01 |
| CHEMBL4287055 | — | — | 1 | 8.96 |
| CHEMBL4294744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285942 | — | EC50 | = | 0.026 | nM | 10.59 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 0.097 | nM | 10.01 |
| CHEMBL4287055 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4294744 | — | EC50 | = | 0.00048 | nM | - |