Assay Detail
Functional
CHEMBL4260281
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Cytotoxicity against arrested non-proliferative human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
7-Deacetyl-10-alkylthiocolchicine derivatives - new compounds with potent anticancer and fungicidal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.16 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298240 | — | — | 1 | 8.02 |
| CHEMBL4293744 | — | — | 1 | 7.57 |
| CHEMBL4292636 | — | — | 1 | 7.34 |
| CHEMBL4284332 | — | — | 1 | 7.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.89 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.68 |
| CHEMBL4284759 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298240 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4293744 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4292636 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4284332 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL107 | COLCHICINE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4284759 | — | IC50 | = | 409.0 | nM | 6.39 |