Assay Detail
Binding
CHEMBL4260299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Pseudomonas aeruginosa PqsA assessed as decrease in formation of anthranilyl-CoA by spectrophotometric method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Anthranilate--CoA ligase (CHEMBL4295626) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Publication
Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.01 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371502 | — | — | 1 | 7.06 |
| CHEMBL377483 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371502 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL377483 | — | Ki | = | 109.0 | nM | 6.96 |