Assay Detail
Binding
CHEMBL4260388
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Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.49 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291231 | — | — | 1 | 5.92 |
| CHEMBL4281005 | — | — | 1 | 5.92 |
| CHEMBL4290806 | — | — | 1 | 5.80 |
| CHEMBL4282946 | — | — | 1 | 5.80 |
| CHEMBL4293890 | — | — | 1 | 5.77 |
| CHEMBL4280586 | — | — | 1 | 5.75 |
| CHEMBL4284039 | — | — | 1 | 5.70 |
| CHEMBL419432 | — | — | 1 | 5.68 |
| CHEMBL4291976 | — | — | 1 | 5.57 |
| CHEMBL4294633 | — | — | 1 | 5.55 |
| CHEMBL4282611 | — | — | 1 | 5.48 |
| CHEMBL4284107 | — | — | 1 | 5.47 |
| CHEMBL4288906 | — | — | 1 | 5.44 |
| CHEMBL4279482 | — | — | 1 | 5.40 |
| CHEMBL4278741 | — | — | 1 | 5.39 |
| CHEMBL4289410 | — | — | 1 | 5.38 |
| CHEMBL4285991 | — | — | 1 | 5.32 |
| CHEMBL4279857 | — | — | 1 | 5.19 |
| CHEMBL167970 | — | — | 1 | 4.95 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.90 |
| CHEMBL4287392 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291231 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4281005 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4290806 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4282946 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4293890 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4280586 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4284039 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL419432 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4291976 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4294633 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4282611 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4284107 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4288906 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4279482 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4278741 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4289410 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4285991 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4279857 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL167970 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4287392 | — | IC50 | = | 13700.0 | nM | 4.86 |