Assay Detail
Binding
CHEMBL4260481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human Kv7.3/7.5 by patch clamp method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Voltage-gated potassium channel KCNQ3/KCNQ5 (CHEMBL3883311) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.59 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278049 | — | — | 1 | 7.10 |
| CHEMBL4288707 | — | — | 1 | 6.70 |
| CHEMBL4277250 | — | — | 1 | 6.60 |
| CHEMBL4287894 | — | — | 1 | 6.44 |
| CHEMBL4287478 | — | — | 1 | 6.40 |
| CHEMBL1703636 | — | — | 1 | 6.30 |
| CHEMBL402146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278049 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4288707 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4277250 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4287894 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4287478 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1703636 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL402146 | — | EC50 | > | 10000.0 | nM | - |