Assay Detail
Binding
CHEMBL4260786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Mesulergine from human 5-HT2C receptor expressed in HEK293FlpIN cells by radioligand binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.92 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291048 | — | — | 1 | 6.40 |
| CHEMBL4293307 | — | — | 1 | 6.13 |
| CHEMBL47050 | PENFLURIDOL | 2.0 | 1 | 6.05 |
| CHEMBL4278465 | — | — | 1 | 5.95 |
| CHEMBL4287623 | — | — | 1 | 5.79 |
| CHEMBL1644978 | — | — | 1 | 5.77 |
| CHEMBL1644980 | — | — | 1 | 5.67 |
| CHEMBL4282702 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291048 | — | Ki | = | 402.0 | nM | 6.40 |
| CHEMBL4293307 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL47050 | PENFLURIDOL | Ki | = | 881.0 | nM | 6.05 |
| CHEMBL4278465 | — | Ki | = | 1126.0 | nM | 5.95 |
| CHEMBL4287623 | — | Ki | = | 1603.0 | nM | 5.79 |
| CHEMBL1644978 | — | Ki | = | 1712.0 | nM | 5.77 |
| CHEMBL1644980 | — | Ki | = | 2131.0 | nM | 5.67 |
| CHEMBL4282702 | — | Ki | = | 2548.0 | nM | 5.59 |