Assay Detail
ADMET
CHEMBL4260824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]WIN35428 from human DAT expressed in HEK cells by radioligand binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.02 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644980 | — | — | 1 | 6.92 |
| CHEMBL1644978 | — | — | 1 | 6.28 |
| CHEMBL4293307 | — | — | 1 | 6.21 |
| CHEMBL4291048 | — | — | 1 | 5.92 |
| CHEMBL47050 | PENFLURIDOL | 2.0 | 1 | 5.77 |
| CHEMBL4278465 | — | — | 1 | 5.00 |
| CHEMBL4287623 | — | — | 1 | - |
| CHEMBL4282702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644980 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL1644978 | — | Ki | = | 529.0 | nM | 6.28 |
| CHEMBL4293307 | — | Ki | = | 622.0 | nM | 6.21 |
| CHEMBL4291048 | — | Ki | = | 1191.0 | nM | 5.92 |
| CHEMBL47050 | PENFLURIDOL | Ki | = | 1714.0 | nM | 5.77 |
| CHEMBL4278465 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4287623 | — | Ki | - | — | - | |
| CHEMBL4282702 | — | Ki | - | — | - |