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Assay Detail

CHEMBL4260967

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Functional
Agonist activity at dopamine D5 receptor (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(1B) dopamine receptor (CHEMBL1850)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization.
Davoren JE, Nason D, Coe J, Dlugolenski K, Helal C, Harris AR, LaChapelle E, Liang S, Liu Y, O'Connor R, Orozco CC, Rai BK, Salafia M, Samas B, Xu W, Kozak R, Gray D.
J Med Chem (2018) 61 : 11384 -11397
PubMed 30431269 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.32 8.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4277264 1 8.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4277264 Ki = 4.8 nM 8.32