Assay Detail
ADMET
CHEMBL4263060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTox green assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-Hydroxy-<i>N</i>-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.18 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536151 | IMD-0354 | 1.0 | 1 | 6.07 |
| CHEMBL4284710 | — | — | 1 | 4.28 |
| CHEMBL79004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536151 | IMD-0354 | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4284710 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL79004 | — | IC50 | > | 100000.0 | nM | - |