Assay Detail
Binding
CHEMBL4263067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant ALK (unknown origin) after 1 hr by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.02 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 9.33 |
| CHEMBL4278474 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4278474 | — | EC50 | = | 19630.0 | nM | 4.71 |