Assay Detail
Functional
CHEMBL4263092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 2a infected in human Hep2 replicon cells after 3 days by luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Sugar modified pyrimido[4,5-<i>b</i>]indole nucleosides: synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 4.85 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562967 | MERICITABINE | 2.0 | 1 | 6.00 |
| CHEMBL4288693 | — | — | 1 | 5.16 |
| CHEMBL4277791 | — | — | 1 | 5.02 |
| CHEMBL4278035 | — | — | 1 | 4.97 |
| CHEMBL4281923 | — | — | 1 | 4.86 |
| CHEMBL4292112 | — | — | 1 | 4.83 |
| CHEMBL4285350 | — | — | 1 | 4.80 |
| CHEMBL4278184 | — | — | 1 | 4.80 |
| CHEMBL4293171 | — | — | 1 | 4.79 |
| CHEMBL4289528 | — | — | 1 | 4.79 |
| CHEMBL4281646 | — | — | 1 | 4.77 |
| CHEMBL4283000 | — | — | 1 | 4.76 |
| CHEMBL4288155 | — | — | 1 | 4.71 |
| CHEMBL4284758 | — | — | 1 | 4.69 |
| CHEMBL4286099 | — | — | 1 | 4.66 |
| CHEMBL4281487 | — | — | 1 | 4.63 |
| CHEMBL4288440 | — | — | 1 | 4.62 |
| CHEMBL4291863 | — | — | 1 | 4.42 |
| CHEMBL4278874 | — | — | 1 | - |
| CHEMBL4279588 | — | — | 1 | - |
| CHEMBL4292913 | — | — | 1 | - |
| CHEMBL4285074 | — | — | 1 | - |
| CHEMBL4281239 | — | — | 1 | - |
| CHEMBL4293580 | — | — | 1 | - |
| CHEMBL4289792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562967 | MERICITABINE | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4288693 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4277791 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4278035 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4281923 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4292112 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4285350 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4278184 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4293171 | — | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4289528 | — | EC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4281646 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4283000 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL4288155 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4284758 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL4286099 | — | EC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL4281487 | — | EC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL4288440 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4291863 | — | EC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL4278874 | — | EC50 | > | 44400.0 | nM | - |
| CHEMBL4279588 | — | EC50 | > | 44400.0 | nM | - |
| CHEMBL4292913 | — | EC50 | > | 44400.0 | nM | - |
| CHEMBL4285074 | — | EC50 | > | 44400.0 | nM | - |
| CHEMBL4281239 | — | EC50 | > | 44400.0 | nM | - |
| CHEMBL4293580 | — | EC50 | > | 44400.0 | nM | - |
| CHEMBL4289792 | — | EC50 | > | 44400.0 | nM | - |