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Assay Detail

CHEMBL4263140

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Functional
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Intermediate

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Thiosemicarbazone-based selective proliferation inactivators inhibit gastric cancer cell growth, invasion, and migration.
Hu B, Wang B, Zhao B, Guo Q, Li ZH, Zhang XH, Liu GY, Liu Y, Tang Y, Luo F, Du Y, Chen YX, Ma LY, Liu HM.
Medchemcomm (2017) 8 : 2173 -2180
PubMed 30108734 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.60 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4287033 1 5.00
CHEMBL463836 1 4.91
CHEMBL231616 TRIAPINE 3.0 1 4.72
CHEMBL4290447 1 4.54
CHEMBL4289999 1 4.38
CHEMBL4286574 1 4.35
CHEMBL4291063 1 4.31
CHEMBL4293444 1 -
CHEMBL4291549 1 -
CHEMBL4278614 1 -
CHEMBL4285958 1 -
CHEMBL4279315 1 -
CHEMBL4293378 1 -
CHEMBL4282767 1 -
CHEMBL4278239 1 -
CHEMBL4286155 1 -
CHEMBL4293944 1 -
CHEMBL4286043 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4287033 IC50 = 9990.0 nM 5.00
CHEMBL463836 IC50 = 12380.0 nM 4.91
CHEMBL231616 TRIAPINE IC50 = 18850.0 nM 4.72
CHEMBL4290447 IC50 = 29150.0 nM 4.54
CHEMBL4289999 IC50 = 41920.0 nM 4.38
CHEMBL4286574 IC50 = 44640.0 nM 4.35
CHEMBL4291063 IC50 = 49230.0 nM 4.31
CHEMBL4293444 IC50 > 64000.0 nM -
CHEMBL4291549 IC50 > 64000.0 nM -
CHEMBL4278614 IC50 > 64000.0 nM -
CHEMBL4285958 IC50 > 64000.0 nM -
CHEMBL4279315 IC50 > 64000.0 nM -
CHEMBL4293378 IC50 > 64000.0 nM -
CHEMBL4282767 IC50 > 64000.0 nM -
CHEMBL4278239 IC50 > 64000.0 nM -
CHEMBL4286155 IC50 > 64000.0 nM -
CHEMBL4293944 IC50 > 64000.0 nM -
CHEMBL4286043 IC50 > 64000.0 nM -