Assay Detail
Functional
CHEMBL4263263
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Antiproliferative activity against human LS174T cells assessed as inhibition of cell proliferation after 4 days by Vi-Cell cell viability analyzer based method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS174T |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phenylethynyl-substituted Heterocycles Inhibit Cyclin D1 and Induce the Expression of Cyclin-dependent Kinase Inhibitor p21Wif1/Cip1 in Colorectal Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.97 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285353 | — | — | 1 | 8.38 |
| CHEMBL4277401 | — | — | 1 | 7.93 |
| CHEMBL3309937 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285353 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4277401 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL3309937 | — | IC50 | = | 25.1 | nM | 7.60 |