Assay Detail

CHEMBL4263540

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Functional

Antileishmanial activity against Leishmania donovani amastigotes

ChEMBL ↗

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Target

Leishmania donovani (CHEMBL367) ↗

Open DB target context

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Leishmania donovani (CHEMBL367) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Leishmania donovani

CHEMBL367

Anchored from Assay target.

Protein identity Leishmania donovani

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Leishmania donovani
Confidence	1 — Organism
Curated By	Intermediate

Target

Leishmania donovani (CHEMBL367) ↗

Type	ORGANISM
Organism	Leishmania donovani

Publication

Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase.

Chibli LA, Schmidt TJ, Nonato MC, Calil FA, Da Costa FB.
Eur J Med Chem (2018) 157 : 852 -866
PubMed 30145372 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.82	6.35

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL371358	GOIAZENSOLIDE	—	1	6.35
CHEMBL1173297	—	—	1	5.29

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL371358	GOIAZENSOLIDE	IC50	=	450.0	nM	6.35
CHEMBL1173297	—	IC50	=	5140.0	nM	5.29