Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4265267

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-PYY(1 to 36 residues) from mouse Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 5 (CHEMBL3802)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Design of Y2 Receptor Selective and Proteolytically Stable PYY3-36 Analogues.
Østergaard S, Kofoed J, Paulsson JF, Madsen KG, Jorgensen R, Wulff BS.
J Med Chem (2018) 61 : 10519 -10530
PubMed 30399314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 7.19 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4281479 2 9.30
CHEMBL4276961 2 8.60
CHEMBL4292105 2 7.60
CHEMBL4280392 2 6.70
CHEMBL4287058 2 6.20
CHEMBL4290445 2 6.20
CHEMBL4283257 2 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4281479 EC50 = 0.5 nM 9.30
CHEMBL4281479 EC50 = 0.5012 nM 9.30
CHEMBL4276961 EC50 = 2.5 nM 8.60
CHEMBL4276961 EC50 = 2.512 nM 8.60
CHEMBL4292105 EC50 = 25.0 nM 7.60
CHEMBL4292105 EC50 = 25.12 nM 7.60
CHEMBL4280392 EC50 = 200.0 nM 6.70
CHEMBL4280392 EC50 = 199.53 nM 6.70
CHEMBL4287058 EC50 = 630.0 nM 6.20
CHEMBL4287058 EC50 = 630.96 nM 6.20
CHEMBL4290445 EC50 = 630.0 nM 6.20
CHEMBL4290445 EC50 = 630.96 nM 6.20
CHEMBL4283257 EC50 = 2000.0 nM 5.70
CHEMBL4283257 EC50 = 1995.26 nM 5.70