Assay Detail
Binding
CHEMBL4265356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human alpha7 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh-induced channel current after 5 mins at -70 mV holding potential by two electrode voltage clamp method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.58 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4291079 | — | — | 1 | 8.19 |
| CHEMBL4293646 | — | — | 1 | 7.91 |
| CHEMBL4280452 | — | — | 1 | 7.61 |
| CHEMBL1257065 | STILONIUM IODIDE | 2.0 | 1 | 7.39 |
| CHEMBL4287656 | — | — | 1 | 7.33 |
| CHEMBL4285772 | — | — | 1 | 7.04 |
| CHEMBL4276776 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4291079 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4293646 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL4280452 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL1257065 | STILONIUM IODIDE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4287656 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4285772 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4276776 | — | IC50 | > | 10000.0 | nM | - |