Assay Detail
Functional
CHEMBL4265678
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro antitumor activity of novel alkenyl derivatives of pyridoxine, bioisosteric analogs of feruloyl methane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.39 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4295033 | — | — | 1 | 5.96 |
| CHEMBL4281914 | — | — | 1 | 5.89 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.85 |
| CHEMBL4294345 | — | — | 1 | 5.66 |
| CHEMBL4287109 | — | — | 1 | 5.62 |
| CHEMBL4288205 | — | — | 1 | 5.54 |
| CHEMBL4292030 | — | — | 1 | 5.41 |
| CHEMBL4279876 | — | — | 1 | 5.39 |
| CHEMBL4283750 | — | — | 1 | 5.34 |
| CHEMBL4284361 | — | — | 1 | 5.18 |
| CHEMBL4285673 | — | — | 1 | 5.14 |
| CHEMBL4291615 | — | — | 1 | 4.57 |
| CHEMBL106509 | DEHYDROZINGERONE | — | 1 | 4.51 |
| CHEMBL4280299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4295033 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4281914 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4294345 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4287109 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4288205 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4292030 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4279876 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4283750 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4284361 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4285673 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4291615 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL106509 | DEHYDROZINGERONE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4280299 | — | IC50 | = | 398000.0 | nM | - |