Assay Detail

CHEMBL4266311

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Binding

Inhibition of recombinant His-tagged human Aurora A kinase expressed in Escherichia coli using Tetra-Kemptide and [gamma-33P]-ATP by liquid scintillation counting method

ChEMBL ↗

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Target

Aurora kinase A (CHEMBL4722) ↗

Open DB target context

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Aurora kinase A (CHEMBL4722) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Aurora kinase A

CHEMBL4722

Anchored from Assay target.

Protein identity Aurora kinase A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Aurora kinase A (CHEMBL4722) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies.

Borisa AC, Bhatt HG.
Eur J Med Chem (2017) 140 : 1 -19
PubMed 28918096 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.19	10.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3600873	MK-5108	1.0	1	10.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3600873	MK-5108	IC50	=	0.064	nM	10.19