Assay Detail
Binding
CHEMBL4266500
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression system in presence of 25 uM ATP
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK2 (CHEMBL4225) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.09 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4290222 | — | — | 1 | 7.41 |
| CHEMBL4278882 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4290222 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4278882 | — | IC50 | = | 175.0 | nM | 6.76 |